basic objective of this lecture is to present on Themes in “Of Mice and Men”. The title of the novel comes from a poem by the Scottish poet Robert Burns (1759 -96). Of Mice and Men teaches a grim lesson about the nature of human existence. Nearly all of the characters, including George, Lennie, Candy, Crooks, and Curley’s wife, admit, at one time or another, to having a profound sense of loneliness and isolation.