This article describe about Mitochondrial Donation, which is an IVF technique that could prevent transmission of mitochondrial disease from mother to child. It is a special form of in vitro fertilization in which the future baby’s mitochondrial DNA comes from a third party. The two most common techniques in mitochondrial donation are pronuclear transfer and maternal spindle transfer. They involve transferring nuclear genetic material from the affected mother’s egg into a donor egg that has had its nuclear DNA removed and retains only its healthy mitochondrial DNA; the resulting child therefore does not inherit the mitochondrial disease.