The word “antiobesity potential” refers to a substance’s, treatment’s, or intervention’s ability to battle or prevent obesity, a medical condition characterized by an abnormal accumulation of body fat. Obesity is a multifaceted disease impacted by genetic, environmental, behavioral, and metabolic variables. Obesity management and prevention are critical because it is linked to a variety of health problems, including heart disease, diabetes, some cancers, and others.
Using obesity model mice, researchers investigated the antiobesity benefits of Mallotus fustians extract from Hainan Island, China. As a consequence, Mallotus furetianus extract dramatically lowered the body weight and adipose tissue weight of obese model mice. Fatty liver was controlled, and adipocyte size was reduced in adipose tissue. Further research into the mechanism found that fat creation is suppressed by lowering the expression of multiple transcription factors involved in adipocyte development.
Our research group is searching for food ingredients with antiobesity effects, based on the idea that if we can find and incorporate them into our daily diets, we can contribute to people’s health and longevity.
Professor Kojima
Obesity has become a major risk factor for a variety of lifestyle disorders such as diabetes and hypertension, necessitating novel strategies to address it.
A multi-institutional research group lead by Associate Professor Akiko Kojima of Osaka Metropolitan University’s Graduate School of Human Life and Ecology has achieved great headway in the fight against obesity. The researchers had previously undertaken a study on the benefits of a Mallotus furetianus (MFE) extract on the prevention of fatty liver, but the antiobesity actions of MFE and its processes had not been explored until now.
The researchers used obese model mice to test the antiobesity properties of MFEextract, and the findings were astounding. MFE treatment effectively reduced the rise in body weight and adipose tissue weight, as well as morphological changes in the obesity model mice’s liver and adipose tissue. Fat synthesis was inhibited by reducing the expression of many transcription factors involved in adipocyte development, according to further studies.
“Our research group is searching for food ingredients with antiobesity effects, based on the idea that if we can find and incorporate them into our daily diets, we can contribute to people’s health and longevity,” stated Professor Kojima.
“These results not only suggest a link between Mallotus furetianus extract and antiobesity effects but also indicate its potential as a new food ingredient with antiobesity properties.”
