Major objective of this lecture is to present on process of Cleavage. Here briefly describe on what happens after cleavage begins and how does a single celled zygote become a gastrula. After fertilization, the development of a multicellular organism proceeds by a process called cleavage, a series of mitotic divisions whereby the enormous volume of egg cytoplasm is divided into numerous smaller, nucleated cells. Here also describe on early human development and human prenatal development.