General purpose of this lecture is to presentation on Cardiovascular System of heart. Here provide a detailed description of superficial and internal anatomy in the heart, including the pericardium, myocardium and the heart muscle. Here also explain the functioning in the valves of the heart and how they relate to the center sounds and discuss the conductive pathway in the heart, and relate that to clinical uses in the ECG. Finally explain Cardiac Muscle, Fibrous Skeleton, Mitral Valve Prolapse, Coronary Circulation, Coronary Artery Disease and Myocardial Infarction with pictures.