According to the findings of an international, randomized, double-blind, placebo-controlled phase 3 clinical trial, adding the androgen-receptor inhibitor darolutamide to androgen-deprivation therapy and chemotherapy increases the survival of men with metastatic, hormone-sensitive prostate cancer.....
Up to 45 percent of patients with Duchenne muscular dystrophy (DMD), a chronic muscle-wasting condition, may benefit from a new “cocktail” medicine being developed at the University of Alberta. Duchenne muscular dystrophy is a severe, progressive muscle-wasting condition that causes movement .....
Apples and other fruits are frequently sprayed with a fungicide before transit to prevent rotting and improve shelf life. The method preserves freshness, but it could be a double-edged sword: it could aid in the selection and spread of multi-drug resistance pathogenic yeasts. Drug resistance occu.....
NMD, or nonsense-mediated RNA decay, is an evolutionarily conserved biological mechanism for the degradation of potentially faulty messenger RNAs, or mRNAs. It functions as an RNA quality control and gene regulatory mechanism by decreasing gene expression mistakes. Neurological disorders, immunol.....
According to a new study, the malaria medicine hydroxychloroquine blocks mechanisms that generate cisplatin resistance in head and neck tumors and restores cisplatin’s tumor-killing properties in animal models. The findings, which were published today in the Proceedings of the National Acad.....
Clinical trials, which verify a medicine’s efficacy and safety, are a stumbling block that must be overcome before a new treatment can be released to the market. It would be ideal to conduct them on humans, but due to strict ethical requirements, patient availability, and limited financing,.....
A stimulator device is implanted beneath the skin in the chest, with a wire coiled around the vagus nerve in the neck. Vagus nerve stimulation (VNS) is sometimes referred to as a “pacemaker for the brain.” It works by giving frequent, mild electrical pulses to the brain, which helps to preven.....
Scientists have discovered a novel therapeutic medication that can overcome antibiotic resistance in bacteria that cause sepsis, pneumonia, and urinary tract infections, among other illnesses. Carbapenems, such as meropenem, are a class of antibiotics that are often used as a “last option&#.....
In recent years, cancer chemotherapy has experienced a paradigm change, with classic treatments such as broad-spectrum cytotoxic medicines being supplemented or replaced by drugs that target specific genes thought to be involved in the disease’s origin and progression. When researchers used.....
A proof-of-concept experiment sponsored by the Universities of Birmingham and University Hospitals Birmingham NHS Foundation Trust has discovered a medication that may help some COVID-19 pneumonia patients. COVID-19 pneumonia is a life-threatening infection. Pneumonia is a lung infection that cau.....
Researchers at Miami University in Ohio have perfected a novel technique that will enable scientists to assess how potential inhibitors affect antibiotic-resistant bacteria. Native state mass spectrometry is a technology that allows scientists to quickly find the best candidates for effective med.....
In 38 men and women with Attention Deficit Hyperactivity Disorder (ADHD), tests of a medication known to boost brain activity showed early success in lowering symptoms of slow cognitive pace. One of the most frequent neurodevelopmental issues in childhood is Attention Deficit Hyperactivity Disord.....