According to a new study from the University of Eastern Finland, regular physical exercise modifies the body’s metabolite profile, and many of these changes are linked to a lower risk of type 2 diabetes.
More than 7,000 males were included in the study, and they were monitored for eight years. Men who engaged in the most physical exercise had a 39 percent lower risk of type 2 diabetes than men who did not.
Physical activity was linked to the levels of 198 metabolites, or molecules created as a function of the body’s metabolism, with greater physical activity having an impact on some of the same metabolites previously linked to a health-promoting diet. Furthermore, increasing physical activity enhances insulin secretion, according to the research.
Kind 2 diabetes is the most frequent type. It’s a chronic illness that prevents your body from properly using insulin. Insulin resistance is a term used to describe the condition of people with type 2 diabetes. This type of diabetes is more common in people in their forties and fifties.
The study participants’ fasting glucose samples yielded a total of 1,260 metabolites. The relationship between physical activity and metabolite profile has never been explored in such depth or with such a large cohort. Indeed, this study, which was published in Metabolites, is the first to show a link between a variety of metabolites and physical activity.
In the METabolic Syndrome In Men (METSIM) study, researchers looked at the relationship between physical activity and metabolite profile, insulin sensitivity, insulin secretion, and the risk of type 2 diabetes in men. At the start of the trial, none of the individuals had diabetes.
The individuals completed a physical activity questionnaire at the start of the trial and again eight years later, as well as an oral glucose tolerance test and metabolite analysis from a fasting glucose sample.
Men were divided into four groups based on their physical activity: those who were physically inactive, those who were physically active only occasionally, those who were physically active on a regular basis but no more than twice a week, and those who were physically active on a regular basis but at least three times a week. A single physical activity session was defined as lasting at least 30 minutes.
Type 2 diabetes is most common in those over 45, but it is increasingly affecting an increasing number of adolescents, teenagers, and young adults. Type 2 diabetes symptoms might be so subtle that they go unnoticed. It affects around 8 million people who are unaware of it.
Physical exercise was linked to the levels of 198 different metabolites. Physical exercise, among other things, altered the levels of numerous lipids in a way that has been linked to a lower risk of type 2 diabetes in earlier studies.
Previous research has found that a health-promoting diet has some similar relationships with unsaturated fatty acid levels, for example. Steroids, amino acids, imidazoles, carboxylic acids, and hydroxy acids were found as completely new metabolic biomarkers connected with physical exercise by the researchers.
When compared to males who were physically inactive, the risk of acquiring type 2 diabetes was 39 percent lower for men who were physically the most active, and 30 percent lower for men who were physically active no more than twice a week.
Men who increased their physical activity during the follow-up had lower fasting glucose and insulin levels, as well as improved insulin sensitivity and secretion.
Despite multiple research, the link between physical exercise and insulin secretion has remained a mystery. Increased physical exercise enhances insulin secretion, according to a new study.
