This article focus to Discuss on Differentiation Rules, in calculus point of view. Many differentiation rules can be proven using the limit definition of the derivative and are also useful in finding the derivatives of applicable functions. To eliminate the need of using the formal definition for every application of the derivative. Some other important formulas are: If f( x) = c, where c is a constant, the f′ ( x) = 0. If f( x) = c • g( x), then f′ ( x) = c • g′ ( x) and Sum Rule: If f( x) = g( x) + h( x), then f′ ( x) = g′ ( x) + h′ ( x) and some other are explain in this article.